Oxycodone is a medicine that is used to help treat severe pain. Common side effects include constipation, nausea, vomiting, stomach pain, headache, and dizziness. Do not drive or do other. Oxycodone is an opioid medication that treats severe pain. It works by blocking pain signals in your brain. The most common side effects of oxycodone include delayed gastric emptying, euphoria, anxiolysis (a reduction in anxiety), feelings of relaxation, and respiratory depression. [49] Learn more about the side effects of oxycodone (oxy), both short and long-term effects, and how to find treatment Oxycodone is an opioid medication that takes on pain. It comes in tablet, capsule, or liquid form. Understand the uses, side effects, and precautions. Oxycodone acts on the central nervous system (CNS) to relieve pain. Oxycodone extended-release capsules or tablets should not be used if you need pain medicine for just a short time, such as when recovering from surgery. Learn what oxycodone actually feels like, how it works in the body, and why its effects shift with dose, time, and formulation. Learn about the side effects of oxycodone, from common to rare, for consumers and healthcare professionals. Oxycodone (Roxicodone, Oxycontin) is a prescription opioid that treats pain. Common oxycodone side effects include constipation, drowsiness, and nausea. Dizziness can also occur. Serious side effects include misuse and overdose. And withdrawal symptoms can occur if you stop oxycodone abruptly. Oxycodone is used to manage pain severe enough to require an opioid pain medicine when other pain medicines do not treat pain well enough, or are not tolerated. Includes oxycodone side effects, dose, reviews, warnings, and more.